TGTBT Department

Ever had it before? Well you got it again.
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TGTBT Department

Post by Pyrrho » Tue May 06, 2014 8:04 pm

Wonder drug!!1!!1elevensies!!11!!

http://www.hawaiibusiness.com/Hawaii-Bu ... nder-Drug/

A Hawaii biotech startup has synthesized a version of astaxanthin, a drug that might become a powerful treatment for all kinds of inflammatory illnesses ranging from heart disease to diabetes. But first, the company must navigate the possibilities and challenges posed by FDA-required testing, venture capital, Big Pharma and a reverse merger. Success isn’t inevitable, because, as the founder acknowledges, even good ideas can fail.
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Re: TGTBT Department

Post by DrMatt » Wed Jun 18, 2014 3:28 am

Meanwhile, <ironic>skeptical</ironic> insight for the gravitationally challenged...

SGML tags supplied for the truly stupid folks who frequent this web site.
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Re: TGTBT Department

Post by Anaxagoras » Wed Jun 18, 2014 4:02 am

I forget where I heard this rule of thumb, but I think it applies here:

When a headline ends in a question mark, the answer is usually 'no.'
A fool thinks himself to be wise, but a wise man knows himself to be a fool.
William Shakespeare

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Re: TGTBT Department

Post by Doctor X » Wed Jun 18, 2014 4:11 am

Testing should not be a "challenge."

It should be "confirmation."

--J.D.
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Re: TGTBT Department

Post by Rob Lister » Wed Jun 18, 2014 10:56 am

Having skimmed the article, it looked pretty straight forward and I didn't see many woo-tells. It's written from a business perspective and so there's no way to glean the real potential of the drug class. There's a little hyperbole about the drug's potential but when have you read a popular press article that didn't have that.

The Big Pharma and VC funding issues mentioned in the article I've heard expressed by folks like Derek Lowe, so I tend to put them in the 'likely' box.

IOW, I'm not discounting it strictly because they're tempted to go down the 'natural remedy' route as a test bed and funding vehicle. Their reasoning is pretty sound: use the profits from the vast natural market to fund the Phase II trials for targeted compounds which are necessary to get Big Pharma to fund the impossibly expensive Phase III trials.

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Re: TGTBT Department

Post by Miles » Sat Jun 28, 2014 8:18 pm

Actually, there is quite a bit of scientific evidence to support the claimed free-radical busting effects of astaxanthin. ''Anti-inflammatory'' agent would be a misnomer, however it is known that oxidative stress can facilitate tissue inflammation. It is a xanthophyll carotenoid, and carotenoids are well-known for their anti-oxidative factor. It is especially effective against peroxyl radicals. It is accepted that oxidative stress and inflammation play a significant role in the pathophysiology of many chronic diseases including carcinomaa and atherosclerotic cardiovascular disease.

http://www.ncbi.nlm.nih.gov/pubmed/22214255
http://www.ncbi.nlm.nih.gov/pubmed/10775364


Conversely it is not a ''wonder drug'' anymore than beta-carotene supplements are a ''wonder drug'', but their effects should not go unheeded.

Anecdote: carotenoids are a staple of my family's diet. An instance large in carotenoids is always added to what we eat. We rarely contract illness and the effects of ageing are not as apparent in comparison to other families who subscribe to a diet of mostly meat or junk food, which would seem to correspond to the research regarding the effects of carotenoid consumption in large quantities and oxidative stress.
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Re: TGTBT Department

Post by Doctor X » Sat Jun 28, 2014 11:06 pm

Did someone mention:

Image

Derek Lowe? :hyper:







What?

--J.D.
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"It was the criticisms of Doc X, actually, that let me see more clearly how far the hypocrisy had gone."--clarsct
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Re: TGTBT Department

Post by Harikrish » Sun Jun 29, 2014 2:46 am

Doctor X wrote:Did someone mention:

Image

Derek Lowe? :hyper:







What?

--J.D.


Even your mommy had to hold back her fart.


Image

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Re: TGTBT Department

Post by Doctor X » Sun Jun 29, 2014 3:06 am

Image

--J.D.
Mob of the Mean: Free beanie, cattle-prod and Charley Fan Club!
"Doctor X is just treating you the way he treats everyone--as subhuman crap too dumb to breathe in after you breathe out."--Don
DocX: FTW.--sparks
"Doctor X wins again."--Pyrrho
"Never sorry to make a racist Fucktard cry."--His Humble MagNIfIcence
"It was the criticisms of Doc X, actually, that let me see more clearly how far the hypocrisy had gone."--clarsct
"I'd leave it up to Doctor X who has been a benevolent tyrant so far."--Grammatron
"Indeed you are a river to your people.
Shit. That's going to end up in your sig."--Pyrrho
"Try a twelve step program and accept Doctor X as your High Power."--asthmatic camel
"just like Doc X said." --gnome

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Re: TGTBT Department

Post by Harikrish » Sun Jun 29, 2014 1:47 pm

Doctor X wrote:Image

--J.D.

But you just couldn't resist mommy backside. Now that is using your head and not leading with your emotions.

Doctor X wrote:Image

--J.D.

Of course you do, honey. You are looking up my backside.

Image[

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Re: TGTBT Department

Post by Doctor X » Sun Jun 29, 2014 10:05 pm

Image

--J.D.
Mob of the Mean: Free beanie, cattle-prod and Charley Fan Club!
"Doctor X is just treating you the way he treats everyone--as subhuman crap too dumb to breathe in after you breathe out."--Don
DocX: FTW.--sparks
"Doctor X wins again."--Pyrrho
"Never sorry to make a racist Fucktard cry."--His Humble MagNIfIcence
"It was the criticisms of Doc X, actually, that let me see more clearly how far the hypocrisy had gone."--clarsct
"I'd leave it up to Doctor X who has been a benevolent tyrant so far."--Grammatron
"Indeed you are a river to your people.
Shit. That's going to end up in your sig."--Pyrrho
"Try a twelve step program and accept Doctor X as your High Power."--asthmatic camel
"just like Doc X said." --gnome

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Re: TGTBT Department

Post by Harikrish » Thu Jul 03, 2014 6:22 pm

Doctor X wrote:Testing should not be a "challenge."

It should be "confirmation."

--J.D.

You don't handle challenges too well.

[video]http://youtu.be/c_A0GigrQl0[/video]

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Re: TGTBT Department

Post by Doctor X » Fri Jul 04, 2014 2:09 am

I am sorry, thought someone said something.

BWA!HA!HA!HA!HA!HA!HA!HA!

--J.D.
Mob of the Mean: Free beanie, cattle-prod and Charley Fan Club!
"Doctor X is just treating you the way he treats everyone--as subhuman crap too dumb to breathe in after you breathe out."--Don
DocX: FTW.--sparks
"Doctor X wins again."--Pyrrho
"Never sorry to make a racist Fucktard cry."--His Humble MagNIfIcence
"It was the criticisms of Doc X, actually, that let me see more clearly how far the hypocrisy had gone."--clarsct
"I'd leave it up to Doctor X who has been a benevolent tyrant so far."--Grammatron
"Indeed you are a river to your people.
Shit. That's going to end up in your sig."--Pyrrho
"Try a twelve step program and accept Doctor X as your High Power."--asthmatic camel
"just like Doc X said." --gnome

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Re: TGTBT Department

Post by Harikrish » Fri Jul 04, 2014 11:11 am

Doctor X wrote:I am sorry, thought someone said something.

BWA!HA!HA!HA!HA!HA!HA!HA!

--J.D.

You Crying again!!?

[video]http://youtu.be/c_A0GigrQl0[/video]

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Re: TGTBT Department

Post by Doctor X » Fri Jul 04, 2014 10:55 pm

I am sorry, thought someone said something.

BWA!HA!HA!HA!HA!HA!HA!HA!

--J.D.
Mob of the Mean: Free beanie, cattle-prod and Charley Fan Club!
"Doctor X is just treating you the way he treats everyone--as subhuman crap too dumb to breathe in after you breathe out."--Don
DocX: FTW.--sparks
"Doctor X wins again."--Pyrrho
"Never sorry to make a racist Fucktard cry."--His Humble MagNIfIcence
"It was the criticisms of Doc X, actually, that let me see more clearly how far the hypocrisy had gone."--clarsct
"I'd leave it up to Doctor X who has been a benevolent tyrant so far."--Grammatron
"Indeed you are a river to your people.
Shit. That's going to end up in your sig."--Pyrrho
"Try a twelve step program and accept Doctor X as your High Power."--asthmatic camel
"just like Doc X said." --gnome

WS CHAMPIONS X3!!! NBA CHAMPIONS!! Stanley Cup! SB CHAMPIONS X5!!!!!

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Re: TGTBT Department

Post by Harikrish » Sat Jul 05, 2014 4:22 pm

Doctor X wrote:I am sorry, thought someone said something.

BWA!HA!HA!HA!HA!HA!HA!HA!

--J.D.

It was drowned by the sound of your loud crying. Get over it, boy!!!

[video]http://youtu.be/c_A0GigrQl0[/video]

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Re: TGTBT Department

Post by Doctor X » Sat Jul 05, 2014 4:38 pm

And I win again.

--J.D.
Mob of the Mean: Free beanie, cattle-prod and Charley Fan Club!
"Doctor X is just treating you the way he treats everyone--as subhuman crap too dumb to breathe in after you breathe out."--Don
DocX: FTW.--sparks
"Doctor X wins again."--Pyrrho
"Never sorry to make a racist Fucktard cry."--His Humble MagNIfIcence
"It was the criticisms of Doc X, actually, that let me see more clearly how far the hypocrisy had gone."--clarsct
"I'd leave it up to Doctor X who has been a benevolent tyrant so far."--Grammatron
"Indeed you are a river to your people.
Shit. That's going to end up in your sig."--Pyrrho
"Try a twelve step program and accept Doctor X as your High Power."--asthmatic camel
"just like Doc X said." --gnome

WS CHAMPIONS X3!!! NBA CHAMPIONS!! Stanley Cup! SB CHAMPIONS X5!!!!!

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Re: TGTBT Department

Post by Harikrish » Sat Jul 05, 2014 7:00 pm

Doctor X wrote:And I win again.

--J.D.

And you start crying again!!!
[video]http://youtu.be/c_A0GigrQl0[/video]

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Re: TGTBT Department

Post by Doctor X » Sat Jul 05, 2014 11:57 pm

My Bitch justine dances for me as always.

BWA!HA!HA!HA!HA!HA!HA!HA!HA!

--J.D.
Mob of the Mean: Free beanie, cattle-prod and Charley Fan Club!
"Doctor X is just treating you the way he treats everyone--as subhuman crap too dumb to breathe in after you breathe out."--Don
DocX: FTW.--sparks
"Doctor X wins again."--Pyrrho
"Never sorry to make a racist Fucktard cry."--His Humble MagNIfIcence
"It was the criticisms of Doc X, actually, that let me see more clearly how far the hypocrisy had gone."--clarsct
"I'd leave it up to Doctor X who has been a benevolent tyrant so far."--Grammatron
"Indeed you are a river to your people.
Shit. That's going to end up in your sig."--Pyrrho
"Try a twelve step program and accept Doctor X as your High Power."--asthmatic camel
"just like Doc X said." --gnome

WS CHAMPIONS X3!!! NBA CHAMPIONS!! Stanley Cup! SB CHAMPIONS X5!!!!!

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Re: TGTBT Department

Post by Harikrish » Sun Jul 06, 2014 1:09 pm

Doctor X wrote:My Bitch justine dances for me as always.

BWA!HA!HA!HA!HA!HA!HA!HA!HA!

--J.D.

With your head stuck up my backside, that would be difficult honey.


Doctor X wrote:Image

--J.D.

Of course you do, honey. You are looking up my backside.

Image