To my recollection, it was because there were two enantiomers. One of them would have been safe, the other caused damage to development center of limb buds. Checking . . . Wikiing it sort of confirms that. It appears the drug halted angiogenesis, to make a long story short, which will certainly fuck up limb development.Anaxagoras wrote:Even with drugs like thalidomide I'm not sure they ever pinned down the precise mechanism by which the drug caused the birth defect.
Generally, doing anything to a pregnant woman is a "no-no" since how the hell do you test stuff? That being written, you can give some vaccines to pregnant woman--the CDC has nice set of guidelines.You vaccinate kids at a young age before they are sexually active and hopefully it protects them for the rest of their lives.
It should. The idea is to prevent the infection with the virus. Exactly why Zika causes damage to the developing brain may not be known, but they have recovered the virus from fetal brain tissue. Be that as it may, the vaccines being developed should not give you Zika. There are, of course, a number of things you have to rule out to establish safety and efficacy.
In the short term though, I don't know if you vaccinate a pregnant woman or not. Which would be riskier? If there is a high possibility of catching the full disease the risk of vaccinating may be lower.