Gene drive and biowarfare

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Gene drive and biowarfare

Post by Pyrrho » Wed Mar 23, 2016 11:19 pm

Well this is scary:

http://www.statnews.com/2015/11/12/gene ... rror-risk/
Gene drive is a molecular technique that slips a new gene into an organism and guarantees that it will be inherited by offspring and by subsequent generations. That’s possible because gene drive not only introduces a new gene but destroys competitors of that gene. Result: even if the genetically engineered organism mates with a partner carrying a different version of the gene, all of their descendants will carry the engineered gene and express the associated trait.

...

With gene drives, he said in a telephone interview, it might be possible to introduce a toxin-making gene into the salivary glands of malarial mosquitoes so that when they bite they transmit not only that disease but also something quickly lethal. The trait would quickly spread to countless mosquitoes. Or perhaps gene drives could make insects “more hospitable” to dengue or other disease-causing viruses, Adalja speculated, or enable them to expand their range, bringing malaria and other scourges to regions far from the tropics.
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Re: Gene drive and biowarfare

Post by Doctor X » Thu Mar 24, 2016 9:14 am

Actually, an old concept.

Easier to do with a virus. They incorporate in your genome all of the time. Hell, we have remnants of ancient incorporations.

Just make sure it targets germ cell. Then you can pass it on.

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Re: Gene drive and biowarfare

Post by sparks » Thu Mar 24, 2016 10:13 pm

"If I pass the test, can I stay here? I like it here."
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Re: Gene drive and biowarfare

Post by Anaxagoras » Tue May 23, 2017 8:17 am

Could this be the "magic bullet" that can potentially cure all sorts of diseases?

CRISPR kills HIV and eats Zika 'like Pac-man'. Its next target? Cancer
Researchers paired proteins with a process that amplifies RNA which could be used to detect cancer cells

HIV has no cure. It’s not quite the implacable scourge it was throughout the 1980s and 1990s, thanks to education, prophylactics, and drugs like PrEP. But still, no cure.

Part of the problem is HIV’s ability to squirrel itself away inside a cell’s DNA – including the DNA of the immune cells that are supposed to be killing it. The same ability, though, could be HIV’s undoing. All because of CRISPR. You know, CRIPSR: the gene-editing technique that got everyone really excited, then really sceptical, and now cautiously optimistic about curing a bunch of intractable diseases.

Last week, a group of biologists published research detailing how they hid an anti-HIV CRISPR system inside another type of virus capable of sneaking past a host’s immune system. What’s more, the virus replicated and snipped HIV from infected cells along the way. At this stage, it works in mice and rats, not people. But as a proof of concept, it means similar systems could be developed to fight a huge range of diseases — herpes, cystic fibrosis, and all sorts of cancers.
I wonder. Yeah, maintain skepticism, but could this bring about a revolution in medicine similar to antibiotics?

As they say, if something sounds too good to be true, it probably isn't, but then again antibiotics must have seemed almost too good to be true at the beginning. And to be sure, there are downsides to antibiotics too, like they keep losing effectiveness as the wee beasties evolve to tolerate them, resulting in "superbugs" that can't be killed by antibiotics. But this, if it works out, could take it to the next level.

On the downside, if it really works as well as they hope, I suppose it could also be weaponized potentially.

Worth a read. Now might be a good time to invest too.
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Re: Gene drive and biowarfare

Post by Doctor X » Tue May 23, 2017 8:57 am

It will all lead to Mecha and tentacles, Anax.



Mecha and tentacles.




Though some gratuitous "pantsu" so it is not all bad.

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Re: Gene drive and biowarfare

Post by Anaxagoras » Wed Jul 19, 2017 11:27 am

A fool thinks himself to be wise, but a wise man knows himself to be a fool.
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Re: Gene drive and biowarfare

Post by ed » Wed Jul 19, 2017 11:38 am

It seems like a technology far more apt to wide out humanity than nukes.
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Re: Gene drive and biowarfare

Post by Mentat » Wed Jul 19, 2017 5:19 pm

Even if it doesn't cure aids cancer, it still is a highly valuable tool in genetic and pharmaceutical research.
It's "pea-can", man.

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Re: Gene drive and biowarfare

Post by Witness » Thu Jul 20, 2017 3:43 am

Related:
WaPo wrote:Scientists synthesize smallpox cousin in ominous breakthrough

Scientists in Canada have used commercially available genetic material to piece together the extinct horsepox virus, a cousin of the smallpox virus that killed as many as a billion human beings before being eradicated.

The laboratory achievement was reported Thursday in a news article in the journal Science.

The lead researcher in Canada, David Evans, a molecular virologist at the University of Alberta, told The Washington Post that his efforts are aimed at developing vaccines and cancer treatments. There is nothing dangerous about the synthetic horsepox virus, which is not harmful to humans.

He has not yet published his findings in a scientific journal — how to report this kind of research is necessarily fraught for the editors of such journals — but he did discuss them at a meeting on smallpox research last November at the World Health Organization in Geneva. A report on the meeting published by the WHO noted that Evans had received approval from regulatory authorities for his work, but the report added that those authorities may not have fully appreciated the need for regulation of the steps involved in synthesizing a virulent horse pathogen.
https://www.washingtonpost.com/news/spe ... akthrough/