Youth Pills

Ever had it before? Well you got it again.
Anaxagoras
Posts: 29438
Joined: Wed Mar 19, 2008 5:45 am
Location: Yokohama/Tokyo, Japan

Youth Pills

Post by Anaxagoras »

I'm skeptical about this, but it is in Nature, which is supposed to be reputable. It's all just very early studies too, and what exactly it means is unclear to me.

First hint that body’s ‘biological age’ can be reversed
In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’, which tracks a person’s biological age.

A small clinical study in California has suggested for the first time that it might be possible to reverse the body’s epigenetic clock, which measures a person’s biological age.

For one year, nine healthy volunteers took a cocktail of three common drugs — growth hormone and two diabetes medications — and on average shed 2.5 years of their biological ages, measured by analysing marks on a person’s genomes. The participants’ immune systems also showed signs of rejuvenation.

The results were a surprise even to the trial organizers — but researchers caution that the findings are preliminary because the trial was small and did not include a control arm.

Marks of life
The epigenetic clock relies on the body’s epigenome, which comprises chemical modifications, such as methyl groups, that tag DNA. The pattern of these tags changes during the course of life, and tracks a person’s biological age, which can lag behind or exceed chronological age.

Scientists construct epigenetic clocks by selecting sets of DNA-methylation sites across the genome. In the past few years, Horvath — a pioneer in epigenetic-clock research — has developed some of the most accurate ones.

The latest trial was designed mainly to test whether growth hormone could be used safely in humans to restore tissue in the thymus gland. The gland, which is in the chest between the lungs and the breastbone, is crucial for efficient immune function. White blood cells are produced in bone marrow and then mature inside the thymus, where they become specialized T cells that help the body to fight infections and cancers. But the gland starts to shrink after puberty and increasingly becomes clogged with fat.

Evidence from animal and some human studies shows that growth hormone stimulates regeneration of the thymus. But this hormone can also promote diabetes, so the trial included two widely used anti-diabetic drugs, dehydroepiandrosterone (DHEA) and metformin, in the treatment cocktail.
But even if these "epigenetic markers" change with age, why would you assume that the key to "turning back time" is to change the markers? After all, you can make a clock's hands go backwards, but time doesn't go backwards.
shemp
Posts: 7213
Joined: Thu Jun 10, 2004 12:16 pm
Title: inbred shit-for-brains
Location: Planet X

Re: Youth Pills

Post by shemp »

I don't know how significant a study involving nine white men between ages 51-65 can be. But being in that demographic, I'm certainly hoping that this leads to something meaningful that could perhaps get me a few more years of life, especially if I'm still mentally and physically fit enough to enjoy it. But this is very preliminary, and even if it works out, with my luck, it won't be available to the public until I'm either too far gone to benefit or I've already snuffed it.
Last edited by shemp on Sun Sep 08, 2019 9:42 pm, edited 1 time in total.
sparks
Posts: 17272
Joined: Fri Oct 26, 2007 4:13 pm
Location: Friar McWallclocks Bar -- Where time stands still while you lean over!

Re: Youth Pills

Post by sparks »

Another poorly written fluff piece with little basis in science.

Shame on you Nature.
Doctor X
Posts: 74292
Joined: Fri Jun 04, 2004 8:09 pm
Title: Collective Messiah
Location: Your Mom

Re: Youth Pills

Post by Doctor X »

Call me when it reverses atherosclerosis, replaces infarcted tissue, halts and reverses dementing processes, and makes dicks big enough to satisfy shemp's Mom.

–J.D.
Anaxagoras
Posts: 29438
Joined: Wed Mar 19, 2008 5:45 am
Location: Yokohama/Tokyo, Japan

Re: Youth Pills

Post by Anaxagoras »

I wonder if the idea is that, if you can make a car's odometer go backwards, the car will magically get newer again?
sparks
Posts: 17272
Joined: Fri Oct 26, 2007 4:13 pm
Location: Friar McWallclocks Bar -- Where time stands still while you lean over!

Re: Youth Pills

Post by sparks »

Drive backwards then reverse time. And don't forget to watch it all in a mirror or else it won't work.

Or is it eye of newt, hair of toad and some other shit?