SARS-CoV-2 vaccines

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Anaxagoras
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Re: SARS-CoV-2 vaccines

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Oxford-AstraZeneca Vaccine Safety

Article by Steve Novella of the Skeptic's Guide podcast about the blood clotting question.
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Re: SARS-CoV-2 vaccines

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Unlike the other companies, AZ did not conduct the same large-population studies. Instead, they have pooled data from multiple smaller studies performed in several countries at different times. That has inspired less confidence.

https://www.statnews.com/2021/03/15/the ... 9-vaccine/
Approvals for the AstraZeneca vaccine are based on clinical trials that were conducted in the U.K., Brazil, and South Africa. Published analyses of the data pool these clinical trials, an unusual strategy. The trial also included information on a second dosing strategy, which used a lower first dose and waited longer between the two doses.

The EMA’s report on the results says “the dossier suffers from a lack of sponsor oversight which impacts the reporting of data and therefore data integrity.” However, it concludes that “the data are sufficiently robust to allow conclusions regarding efficacy and safety.” The EMA estimated the vaccine was about 60% effective, and the data presented show no signs that patients receiving the vaccine were any more likely to develop blood clots than those on placebo.

AstraZeneca has not filed with the U.S. Food and Drug Administration, which likely means the FDA wants to wait for U.S. results, which could come any day.
However:
The U.S. study, started last September and including 30,000 patients, is, like the studies for the Moderna and Johnson & Johnson vaccines, being run with the U.S. National Institutes of Health. It’s the best hope for settling any questions or concerns about the AstraZeneca vaccine once and for all.
So now we wait.
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Re: SARS-CoV-2 vaccines

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Pyrrho wrote: Sun Mar 21, 2021 11:42 am
So now we wait.
Apparently the wait is over and the results appear to be pretty good.

https://www.astrazeneca.com/media-centr ... int.html#!

I would like to see what numbers the claimed efficacy rates are based on. They are claiming 100% efficacy at preventing severe illness. 79% for testing positive.

From 15 days after the second dose. I would take it. Of course, it's already being used in other countries on a much larger scale.
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Re: SARS-CoV-2 vaccines

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What about the evidences of the autism?

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Pyrrho
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Re: SARS-CoV-2 vaccines

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You get that from the aduvant.
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Re: SARS-CoV-2 vaccines

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Pfizer-BioNTech shot stops covid spread, Israeli study seems to show
The Pfizer Inc. and BioNTech SE coronavirus vaccine appeared to stop the vast majority of recipients in Israel becoming infected, providing the first real-world indication that the immunization will curb transmission of the coronavirus.

The vaccine, which is being rolled out in a national immunization program that began Dec. 20, was 89.4% effective at preventing laboratory-confirmed infections, according to a copy of a draft publication that was posted on Twitter and confirmed by a person familiar with the work. The companies worked with Israel’s Health Ministry on the preliminary observational analysis, which wasn’t peer-reviewed. Some scientists disputed its accuracy.

The results, also reported in Der Spiegel, are the latest in a series of positive data to emerge out of Israel, which has given more coronavirus vaccines per capita than anywhere else in the world. Almost half of the population has had at least one dose of vaccine. Separately, Israeli authorities on Saturday said the Pfizer-BioNTech shot was 99% effective at preventing deaths from the virus.

If confirmed, the early results on lab-tested infections are encouraging because they indicate the vaccine may also prevent asymptomatic carriers from spreading the virus that causes covid-19. That’s not been clear because the clinical trials that tested the safety and efficacy of vaccines focused on the ability to stop symptomatic infections.

“These are the data we need to see to estimate the potential for achieving herd immunity with vaccines,” said Raina MacIntyre, professor of biosecurity at the University of New South Wales in Sydney, in an email Monday. “However, we do need to be able to see the data published in a peer-reviewed journal and to be able to scrutinize the data in detail.”
About 80% of SARS-CoV-2 cases in Israel during the time period of the study, from Jan. 17 to Feb. 6, were caused by the more transmissible strain first identified in the U.K. Israel’s vaccination drive began just before the so-called B.1.1.7 variant emerged, fueling infections and leading to a third lockdown on Jan. 8.
Good news. That's the new dominant variant too.

https://www.worldometers.info/coronavir ... ry/israel/

New infections are down over 86% from the peak in January. Deaths are down 81% and active cases are down 82%. The full immunity hasn't even kicked in yet. Obviously for some it has, but some of the people have been vaccinated more recently or haven't had their second dose yet.
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Re: SARS-CoV-2 vaccines

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https://apnews.com/article/us-news-coro ... 91d06b7da8
But just hours after those encouraging results were reported, the U.S. National Institute of Allergy and Infectious Diseases issued an unusual statement.

The agency said the Data and Safety Monitoring Board “expressed concern that AstraZeneca may have included outdated information from that trial, which may have provided an incomplete view of the efficacy data.”

“We urge the company to work with the DSMB to review the efficacy data and ensure the most accurate, up-to-date efficacy data be made public as quickly as possible,” the statement added.
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Re: SARS-CoV-2 vaccines

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Pfizer says its vaccine 100 percent effective for children aged 12-15
Pfizer Inc. said Wednesday its COVID-19 vaccine was 100 percent effective against the novel coronavirus in children between the ages of 12 and 15, and it will seek emergency use authorization in the United States for the age group in the coming weeks.

Currently, the vaccine developed by Pfizer and its German partner BioNTech SE is approved for use in individuals aged 16 and older.

In a clinical trial involving 2,260 adolescents in the United States, 18 cases of COVID-19, the respiratory illness caused by the virus, were observed in those who had received dummy shots versus none in the vaccinated group.
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Re: SARS-CoV-2 vaccines

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https://www.bloomberg.com/graphics/covi ... tribution/

The average rate of vaccinations in the US has topped 3 million per day for the first time. If this rate can be maintained, it would put the US 3 months away from fully vaccinating 75% of the population.

Also the global rate is over 17 million per day now. At that pace it would take about 21 more months to vaccinate 5.8 billion people (That's how many people are age 16 or over). Also, I'm assuming 2 doses there, but the one-dose J&J vaccine might mean it takes less time. Right now they appear to account for roughly 5% of the doses available in the US. They have promised 100 million doses by the end of June, but that's still 3 months away. However, 100 million doses of the J&J vaccine would be equivalent to 200 million doses of the others.
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Re: SARS-CoV-2 vaccines

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The numbers in Israel look really encouraging to me:

https://www.worldometers.info/coronavir ... ry/israel/

The (average) number of daily new infections peaked on Jan. 14th at 8,395/day. On April 3rd, it was down to 384/day. That's 4.6%. In other words, new infections are down over 95% now from the peak. Active cases peaked on Feb. 5th at 84,784, and reached 6,086 on April 3rd. That's 7.2% or 92.8% down from the peak. Deaths are taking a bit longer but they are also down by about 85% from the peak. They are currently at 10/day but should be in the low single digits within a couple more weeks. It suggests that herd immunity is pretty close, if not already reached. Deaths peaked on Jan. 25th, 11 days after the peak for new infections.
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Re: SARS-CoV-2 vaccines

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This is how far behind Japan is on vaccinations:

Japan starts COVID-19 vaccinations for elderly
KYODO NEWS - 1 hour ago - 09:31
They are finally just starting today. (Up till now has only been health care workers.)
Japan started vaccinating elderly people against the novel coronavirus Monday, the second group to be inoculated following health care workers, as concern over a "fourth wave" of the pandemic grew.

The government is planning to secure enough shots of the vaccine, developed by U.S. pharmaceutical company Pfizer Inc., for roughly 36 million people aged 65 or older and deliver them to municipalities by late June. The elderly tend to develop more serious symptoms than younger people when infected with the virus.
Late June. I guess we'll see whether that happens. Judging from the track record of statements by the government, I'm a little bit skeptical.
The vaccinations come amid growing concern about a resurgence of infections in some areas, including Tokyo as well as Osaka and Kyoto prefectures, after the country fully lifted a second coronavirus state of emergency last month.

The central government has designated prefectures with surging cases as requiring tough measures to control the spread of the virus, but it has stopped short of declaring a third state of emergency, apparently hoping not to complicate efforts to host the postponed Tokyo Olympics and Paralympics this summer.
Because pretending there isn't an emergency won't "complicate" the efforts?

And Japan isn't just lagging behind other advanced countries, it's behind countries like Indonesia, Morocco, and Mongolia, and behind the global average too.
Following the elderly, people with pre-existing conditions, such as diabetes, and those working at elderly care facilities are slated to be inoculated next, after which vaccinations will eventually be extended to the rest of the population.
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Re: SARS-CoV-2 vaccines

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Chinese vaccines ‘don’t have very high protection rates,’ official says

BEIJING — In a rare admission of the weakness of Chinese COVID-19 vaccines, the country’s top disease control official says their effectiveness is low and the government is considering mixing them to give them a boost.

Chinese vaccines “don’t have very high protection rates,” said the director of the China Centers for Disease Control, Gao Fu, at a conference Saturday in the southwestern city of Chengdu.

Beijing has distributed hundreds of millions of doses in other countries while also trying to promote doubt about the effectiveness of Western vaccines.

“It’s now under formal consideration whether we should use different vaccines from different technical lines for the immunization process,” Gao said.

The effectiveness rate of a COVID-19 vaccine from Sinovac, a Chinese developer, at preventing symptomatic infections has been found to be as low as 50.4% by researchers in Brazil. By comparison, the vaccine made by Pfizer has been found to be 97% effective.

Beijing has yet to approve any foreign vaccines for use in China, where the coronavirus emerged in late 2019.

Gao gave no details of possible changes in strategy but mentioned mRNA, a previously experimental technique used by Western vaccine developers while China’s drug makers used traditional technology.
https://www.latimes.com/world-nation/st ... veness-low