Ever had it before? Well you got it again.
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- Posts: 19951
- Joined: Sat Aug 12, 2006 2:01 am
- Title: Je suis devenu Français
- Location: USA
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) also known as 2019-nCoV (2019 Novel Coronavirus) is a virus that causes illnesses ranging from the common cold symptoms to severe effects including death and respiratory distress.
Coronaviruses (CoVs) have formerly been regarded as relatively harmless respiratory pathogens to humans. However, two outbreaks of severe respiratory tract infection, caused by the severe acute respiratory syndrome coronavirus (SARS-CoV) and the Middle East respiratory syndrome coronavirus (MERS-CoV), as a result of zoonotic CoVs crossing the species barrier, caused high pathogenicity and mortality rates in human populations.
Severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) are two highly transmissible and pathogenic viruses that emerged in humans at the beginning of the 21st century. Both viruses likely originated in bats, and genetically diverse coronaviruses that are related to SARS-CoV and MERS-CoV were discovered in bats worldwide.
SARS is thought to have originated in the Guangdong province of China, with
emergence into human populations sometime in November 2002. The 2002-2003
epidemic was characterized by outbreak worldwide including in Canada, Singapore,
Viet Nam and China (originating in Guangdong Province and spreading to major cities
in other areas, including Beijing, Taipei and the Special Administrative Region of Hong
The disease spread internationally along major airline routes and resulted in 8,096
reported SARS cases in 29 countries with 774 deaths (9.6%).1 The exposure settings
for most cases were hospitals and among families and close contacts of hospital
As of September 5, 2003, 438 cases of SARS have been reported in Canada. The first
Canadian cases were identified in March 2003 in people who had traveled to Hong
Kong and returned to Canada. The majority of cases were in Ontario, but cases were
also reported in British Columbia, Alberta, New Brunswick, Prince Edward Island and
The last reported cases of SARS were in a cluster linked to a laboratory worker in China
who was thought to have been infected in April 2004 at a laboratory where the virus was
Health and Long-Term Care
Here, we use structure-guided protein engineering to remove the S1 subunit from the Middle East respiratory syndrome (MERS)-CoV spike (S) glycoprotein and develop stabilized stem (SS) antigens. Vaccination with MERS SS elicits cross-reactive β-CoV antibody responses and protects mice against lethal MERS-CoV challenge.